New IMSVISUAL publication in Lancet Neurology

We are pleased to announce an IMSVISUAL publication by Martinez-Lapiszina et al.

Abstract

BACKGROUND:
Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available.

METHODS:
In this multicentre, cohort study, we collected data about patients (age ≥16 years old) with clinically isolated syndrome, relapsing-remitting multiple sclerosis, and progressive multiple sclerosis. Patients were recruited from centres in Spain, Italy, France, Germany, Czech Republic, Netherlands, Canada, and the USA, with the first cohort starting in 2008 and the latest cohort starting in 2013. We assessed disability worsening using the Expanded Disability Status Scale (EDSS). The pRNFL thickness and macular volume were assessed once at study entry (baseline) by optical coherence tomography (OCT) and was calculated as the mean value of both eyes without optic neuritis for patients without a history of optic neuritis or the value of the non-optic neuritis eye for patients with previous unilateral optic neuritis. Researchers who did the OCT at baseline were masked to EDSS results and the researchers assessing disability with EDSS were masked to OCT results. We estimated the association of pRNFL thickness or macular volume at baseline in eyes without optic neuritis with the risk of subsequent disability worsening by use of proportional hazards models that included OCT metrics and age, disease duration, disability, presence of previous unilateral optic neuritis, and use of disease-modifying therapies as covariates.

FINDINGS:
879 patients with clinically isolated syndrome (n=74), relapsing-remitting multiple sclerosis (n=664), or progressive multiple sclerosis (n=141) were included in the primary analyses. Disability worsening occurred in 252 (29%) of 879 patients with multiple sclerosis after a median follow-up of 2·0 years (range 0·5-5 years). Patients with a pRNFL of less than or equal to 87 μm or less than or equal to 88 μm (measured with Spectralis or Cirrus OCT devices) had double the risk of disability worsening at any time after the first and up to the third years of follow-up (hazard ratio 2·06, 95% CI 1·36-3·11; p=0·001), and the risk was increased by nearly four times after the third and up to the fifth years of follow-up (3·81, 1·63-8·91; p=0·002). We did not identify meaningful associations for macular volume.

INTERPRETATION:
Our results provide evidence of the usefulness of monitoring pRNFL thickness by OCT for prediction of the risk of disability worsening with time in patients with multiple sclerosis.

Find out more on the publisher's website or on our publications page.

Meeting in Barcelona at ECTRIMS 2015

The IMSVISUAL consortium invites you to our meeting at ECTRIMS 2015 in Barcelona.

Date
Friday October 9th from 12 to 2pm

Venue
University Pompeu Fabra
Room: 55.410 (Department of Information and Communication)
Tanger, 122-140
Barcelona

Agenda

  1. Welcome and summary by directors
  2. Membership, organization
  3. Grants and funding
  4. Database, data-sharing and authorship policy
  5. Ongoing projects
  6. New projects (segmentation)
  7. Papers (meta-analysis, APOSTEL)
  8. Next meeting: AAN 2016

Directions
The building is on the side of the well-known Agbar Tower. Tram T4 is stopping in the convention center and stops almost in front of this building. It takes only 10 min.

Invitation and Agenda as PDF

EAN 2015 Satellite Symposium in Berlin

The retina as an interface between neurology and ophthalmology

Time: Friday, June 19th 2015

Location: Friedrich-Kopsch-Hörsaal, Waldeyer-Haus, Institute of Anatomy, Charité Campus Mitte

Session 1: Clinical relevance of visual system examination in neurology

14:50 – 15:00: Welcome
Friedemann Paul (Berlin, DE) & Alexander U. Brandt (Berlin, DE)
Alexander U. Brandt (Berlin, DE) & Pablo Villoslada (Barcelona, ES)

15:00 – 15:30 Key Note: The Afferent Visual Pathway: Defining Structural-Functional Correlations in Central Nervous System Disorders
Fiona Costello (Calgary, CA)

15:30 – 15:45 Clinical neurophysiology of the visual system in multiple sclerosis
Letizia Leocani (Milano, IT)

15:45 – 16:00 Erythropoietin treatment in Optic Neuritis – the TONE trial
Wolf Lagrèze (Freiburg, DE)

16:00 – 16:15 To OCT or not to OCT – is optical coherence tomography ready for routine application in multiple sclerosis?
Axel Petzold (Amsterdam, NL)

16:15 – 16:30 Break
Coffee and Snacks

Session 2: Current research in retinal imaging in multiple sclerosis

Wolf Lagrèze (Freiburg, DE) & Friedemann Paul (Berlin, Germany)

16:30 – 17:00 Key Note: The Role of the Visual System in Monitoring Neurodegeneration: Lessons from the MS Model
Peter Calabresi (Baltimore, US)

17:00 – 17:15 Defining disease heterogeneity in multiple sclerosis with the help of OCT and MRI
Sven Schippling (Zürich, CH)

17:15 – 17:30 Implementing Visual Outcomes in Clinical Trials
Alexander U. Brandt (Berlin, DE)

17:30 – 17:45 Next Generation Retinal Imaging
Ari Green (San Francisco, US)

17:45 – 18:00: Farewell
Friedemann Paul (Berlin, DE) & Alexander U. Brandt (Berlin, DE)

 

Flyer EAN 2015 Satellite Symposium

Meeting in Washington, D.C. at AAN 2015

The IMSVISUAL consortium will have an open meeting at the Annual Academy of Neurology Conference in Washington D.C.

Time: Monday April 20th from 6.15pm – 7.15pm.

Location: Penn Quarter Room, Renaissance Hotel Washington, DC Downtown Hotel, 9th Street Northwest, Washington, DC, United States